Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms
Identifieur interne : 000773 ( Main/Exploration ); précédent : 000772; suivant : 000774Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms
Auteurs : B. Henry [États-Unis] ; S. G Grant [États-Unis] ; G. Klopman [États-Unis] ; H. S Rosenkranz [États-Unis]Source :
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis [ 0027-5107 ] ; 1998.
English descriptors
- Teeft :
- Active chemicals, Assay, Biological activity, Biophore, Biophores, C5ch, Carbon atom, Carcinogenesis, Carcinogenicity, Caspary, Cellular toxicity, Ch5ch, Chemical structure, Chemical structures, Chromosomal, Chromosomal aberrations, Chromosomal mechanisms, Chromosome, Chromosome loss, Chromosome missegregation, Concordance, Database, Dataset, Descriptor, Electrophilic, Environ, Experimental results, Inactivation, Inactive, Inactive chemicals, Inactive molecules, Induction, Informational content, Kinase, Klopman, Locus, Lower predictivity, Lumo, Lymphoma, Major biophores, Major multicase biophores, Mcgregor, Mechanistic, Mechanistic hypotheses, Micronucleus, Minor biophores, Modeling, Molecular events, Mouse lymphoma, Mouse lymphoma cells, Multicase, Multicase program, Multiple mechanisms, Mutagen, Mutagenesis, Mutagenic, Mutagenic events, Mutagenicity, Mutant, Mutation, Mutation assay, Mutation research, Mutational, Mutational events, National toxicology program, Oncogene, Oncogene activation, Other hand, Physical chemical properties, Point mutations, Predictive performance, Predictivity, Ring systems, Rodent, Rodent carcinogenicity, Rosenkranz, Salmonella, Salmonella model, Salmonella mutagenicity, Salmonella mutagenicity assay, Same chemicals, Sister chromatid exchanges, Somatic segregation, Structural basis, Subset, Suppressor, Thymidine, Thymidine kinase locus, Tkqrtky mouse lymphoma cell, Toxicity, Tubulin polymerization, Tumor suppressor gene, Unsupplemented, Vivo induction.
Abstract
Abstract: A database of 209 chemicals tested for induction of forward mutations at the heterozygous thymidine kinase (TK±) locus in L5178Y mouse lymphoma cells was analyzed for structure–activity relationships using the MultiCASE expert system. Consistent with evidence of several contributing biological mechanisms, these studies suggest that such mutations may occur by more than one mechanism. As might be expected, there was evidence for a component involving direct electrophilic attack on the cellular DNA, in a manner previously established as causative in the induction of mutations in Salmonella. In addition, however, there was also strong evidence for another mechanism or mechanisms involving chromosome missegregation, cellular toxicity or an alternate site of action, such as the microtubules.
Url:
DOI: 10.1016/S0027-5107(97)00231-5
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000B60
- to stream Istex, to step Curation: 000B59
- to stream Istex, to step Checkpoint: 000484
- to stream Main, to step Merge: 000781
- to stream Main, to step Curation: 000773
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms</title><author><name sortKey="Henry, B" sort="Henry, B" uniqKey="Henry B" first="B" last="Henry">B. Henry</name></author><author><name sortKey="Grant, S G" sort="Grant, S G" uniqKey="Grant S" first="S. G" last="Grant">S. G Grant</name></author><author><name sortKey="Klopman, G" sort="Klopman, G" uniqKey="Klopman G" first="G" last="Klopman">G. Klopman</name></author><author><name sortKey="Rosenkranz, H S" sort="Rosenkranz, H S" uniqKey="Rosenkranz H" first="H. S" last="Rosenkranz">H. S Rosenkranz</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A3207F44E2E8023C44BB239195A20B52F84CB3CA</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0027-5107(97)00231-5</idno><idno type="url">https://api.istex.fr/document/A3207F44E2E8023C44BB239195A20B52F84CB3CA/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B60</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B60</idno><idno type="wicri:Area/Istex/Curation">000B59</idno><idno type="wicri:Area/Istex/Checkpoint">000484</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000484</idno><idno type="wicri:doubleKey">0027-5107:1998:Henry B:induction:of:forward</idno><idno type="wicri:Area/Main/Merge">000781</idno><idno type="wicri:Area/Main/Curation">000773</idno><idno type="wicri:Area/Main/Exploration">000773</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms</title><author><name sortKey="Henry, B" sort="Henry, B" uniqKey="Henry B" first="B" last="Henry">B. Henry</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Grant, S G" sort="Grant, S G" uniqKey="Grant S" first="S. G" last="Grant">S. G Grant</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Klopman, G" sort="Klopman, G" uniqKey="Klopman G" first="G" last="Klopman">G. Klopman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Rosenkranz, H S" sort="Rosenkranz, H S" uniqKey="Rosenkranz H" first="H. S" last="Rosenkranz">H. S Rosenkranz</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis</title><title level="j" type="abbrev">MUT</title><idno type="ISSN">0027-5107</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">397</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="313">313</biblScope><biblScope unit="page" to="335">335</biblScope></imprint><idno type="ISSN">0027-5107</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0027-5107</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active chemicals</term><term>Assay</term><term>Biological activity</term><term>Biophore</term><term>Biophores</term><term>C5ch</term><term>Carbon atom</term><term>Carcinogenesis</term><term>Carcinogenicity</term><term>Caspary</term><term>Cellular toxicity</term><term>Ch5ch</term><term>Chemical structure</term><term>Chemical structures</term><term>Chromosomal</term><term>Chromosomal aberrations</term><term>Chromosomal mechanisms</term><term>Chromosome</term><term>Chromosome loss</term><term>Chromosome missegregation</term><term>Concordance</term><term>Database</term><term>Dataset</term><term>Descriptor</term><term>Electrophilic</term><term>Environ</term><term>Experimental results</term><term>Inactivation</term><term>Inactive</term><term>Inactive chemicals</term><term>Inactive molecules</term><term>Induction</term><term>Informational content</term><term>Kinase</term><term>Klopman</term><term>Locus</term><term>Lower predictivity</term><term>Lumo</term><term>Lymphoma</term><term>Major biophores</term><term>Major multicase biophores</term><term>Mcgregor</term><term>Mechanistic</term><term>Mechanistic hypotheses</term><term>Micronucleus</term><term>Minor biophores</term><term>Modeling</term><term>Molecular events</term><term>Mouse lymphoma</term><term>Mouse lymphoma cells</term><term>Multicase</term><term>Multicase program</term><term>Multiple mechanisms</term><term>Mutagen</term><term>Mutagenesis</term><term>Mutagenic</term><term>Mutagenic events</term><term>Mutagenicity</term><term>Mutant</term><term>Mutation</term><term>Mutation assay</term><term>Mutation research</term><term>Mutational</term><term>Mutational events</term><term>National toxicology program</term><term>Oncogene</term><term>Oncogene activation</term><term>Other hand</term><term>Physical chemical properties</term><term>Point mutations</term><term>Predictive performance</term><term>Predictivity</term><term>Ring systems</term><term>Rodent</term><term>Rodent carcinogenicity</term><term>Rosenkranz</term><term>Salmonella</term><term>Salmonella model</term><term>Salmonella mutagenicity</term><term>Salmonella mutagenicity assay</term><term>Same chemicals</term><term>Sister chromatid exchanges</term><term>Somatic segregation</term><term>Structural basis</term><term>Subset</term><term>Suppressor</term><term>Thymidine</term><term>Thymidine kinase locus</term><term>Tkqrtky mouse lymphoma cell</term><term>Toxicity</term><term>Tubulin polymerization</term><term>Tumor suppressor gene</term><term>Unsupplemented</term><term>Vivo induction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A database of 209 chemicals tested for induction of forward mutations at the heterozygous thymidine kinase (TK±) locus in L5178Y mouse lymphoma cells was analyzed for structure–activity relationships using the MultiCASE expert system. Consistent with evidence of several contributing biological mechanisms, these studies suggest that such mutations may occur by more than one mechanism. As might be expected, there was evidence for a component involving direct electrophilic attack on the cellular DNA, in a manner previously established as causative in the induction of mutations in Salmonella. In addition, however, there was also strong evidence for another mechanism or mechanisms involving chromosome missegregation, cellular toxicity or an alternate site of action, such as the microtubules.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Henry, B" sort="Henry, B" uniqKey="Henry B" first="B" last="Henry">B. Henry</name></region><name sortKey="Grant, S G" sort="Grant, S G" uniqKey="Grant S" first="S. G" last="Grant">S. G Grant</name><name sortKey="Klopman, G" sort="Klopman, G" uniqKey="Klopman G" first="G" last="Klopman">G. Klopman</name><name sortKey="Rosenkranz, H S" sort="Rosenkranz, H S" uniqKey="Rosenkranz H" first="H. S" last="Rosenkranz">H. S Rosenkranz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000773 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000773 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= BernheimV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A3207F44E2E8023C44BB239195A20B52F84CB3CA
|texte= Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms
}}
| This area was generated with Dilib version V0.6.33. |  |